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Eur Respir J 1991; 4: 377-379
Copyright © ERS Journals Ltd 1991


Case Studies

Pulmonary alveolar proteinosis: prolonged spontaneous remission in two patients

MA Martinez-Lopez, G Gomez-Cerezo, C Villasante, F Molina, S Diaz, J Cobo, and C Medrano

Pulmonary alveolar proteinosis is a rare idiopathic diffuse airspace disease characterized by intra-alveolar accumulation of large quantities of lipoproteinaceous material, with preservation of the lung interstitium. The clinical course of pulmonary alveolar proteinosis is variable. Spontaneous resolution is known to occur in up to a quarter of the cases. We describe two patients with untreated pulmonary alveolar proteinosis who experienced complete clinical, functional and radiographic resolution. In follow-up periods of fourteen and six years, both patients have remained asymptomatic.


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Am. J. Respir. Crit. Care Med.Home page
J. F. Seymour and J. J. Presneill
Pulmonary Alveolar Proteinosis: Progress in the First 44 Years
Am. J. Respir. Crit. Care Med., July 15, 2002; 166(2): 215 - 235.
[Abstract] [Full Text] [PDF]




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Copyright © 1991 by the European Respiratory Society.