HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Yucesoy, B. Articles by Luster, M. I. Search for Related Content PubMed PubMed Citation Articles by Yucesoy, B. Articles by Luster, M. I.

Genetic susceptibility to progressive massive fibrosis in coal miners

¹ Toxicology and Molecular Biology, ³ Biostatistics and Epidemiology, and ⁵ Pathology and Physiology Research Branches, Centers for Disease Control and Prevention (CDC)/National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV, ² Biostatistics, and ⁴ Toxicology Operations Branches, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

CORRESPONDENCE: B. Yucesoy, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, WV 26505-2888, USA. Fax: 1 3042855708. E-mail: byucesoy{at}cdc.gov

Keywords: Coal miners, cytokines, polymorphism, progressive massive fibrosis

Received: June 20, 2007
Accepted January 28, 2008

Progressive massive fibrosis (PMF) is a chronic interstitial lung disease with a complex aetiology that can occur after cumulative dust exposure. A case–control study was conducted to test the hypothesis that single nucleotide polymorphisms (SNPs) within genes involved in inflammatory and fibrotic processes modulate the risk of PMF development.

The study population consisted of 648 underground coal miners participating in the National Coal Workers Autopsy Study, of which 304 were diagnosed with PMF. SNPs that influence the regulation of interleukin (IL)-1, IL-6, tumour necrosis factor-, transforming growth factor-β1, vascular endothelial growth factor (VEGF), epidermal growth factor intercellular cell adhesion molecule (ICAM)-1 and matrix metalloproteinase-2 genes were determined using a 5'-nuclease real-time PCR assay.

There were no significant differences in the distribution of any individual SNP or haplotype between the PMF and control groups. However, the polygenotype of VEGF +405/ICAM-1 +241/IL-6 -174 (C-A-G) conferred an increased risk for PMF (odds ratio 3.4, 95% confidence interval 1.3–8.8).

The present study suggests that the examined genetic variations that help regulate inflammatory and fibrotic processes are unlikely to strongly influence susceptibility to this interstitial lung disease, although the role of vascular endothelial growth factor, intercellular cell adhesion molecule-1 and interleukin-6 polymorphisms in the development of progressive massive fibrosis may require further investigation.