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1 Dept of Pulmonary Medicine, Sahlgrenska University Hospital, 2 Dept of Nursing, University of Göteborg, and 3 Health Care Research Unit, Dept of Internal Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
CORRESPONDENCE: C.P. Engström, Dept of Pulmonary Medicine, Sahlgrenska University Hospital, SE-413 45, Göteborg, Sweden. Fax: 46 31824904
Keywords: chronic obstructive pulmonary disease, Hospital Anxiety and Depression Scale, mood, quality of life, Sickness Impact Profile, St George’s Respiratory Questionnaire
Received: May 16, 2000
Accepted February 20, 2001
This study was supported by a grant from The Swedish Council for Social Research.
Although research has consistently demonstrated that chronic obstructive pulmonary disease (COPD) impairs health-related quality of life (HRQL), little agreement has been evidenced regarding the factors identified as contributing to impaired HRQL. The aim was to study such factors using well established generic and specific HRQL instruments.
The patients (n=68) were stratified by forced expiratory volume in one second (FEV1) to represent a wide range of disease severity. Pulmonary function, blood gases and 6-min walking distance test (6MWD
The strength of the impact of COPD on HRQL was represented along a continuum ranging from lung function, functional status (physical and psychosocial) to wellbeing. Although correlations between FEV1 versus SGRQ total and SIP overall scores (r=–0.42 and –0.32) were stronger than previously reported, multiple regression analyses showed that lung function contributed little to the variance when dyspnoea-related limitation, depression scores and 6MWD
Physiological, functional and psychosocial consequences of chronic obstructive pulmonary disease are only poorly to moderately related to each other. The present study concludes that a comprehensive assessment of the effects of chronic obstructive pulmonary disease requires a battery of instruments that not only tap the disease-specific effects, but also the overall burden of the disease on everyday functioning and emotional wellbeing.
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