| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
INSERM Unité 492, Dépt de Physiologie and Services de Réanimation Médicale et Pneumologie, Hôpital Henri-Mondor, Créteil, France
CORRESPONDENCE: C. Delclaux, INSERM U492, Faculté de Médecine, 8, rue du Général Sarrail, 94010, Créteil, France. Fax: 33 148981777
Keywords: acute respiratory distress syndrome, animal study, bronchoalveolar lavage, human study, Pseudomonas aeruginosa pneumonia
Received: August 29, 2000
Accepted January 31, 2001
Vascular endothelial growth factor (VEGF) is a potent angiogenic and endothelial survival factor, which is abundantly expressed in the normal lung. Conceivably, VEGF may be released by numerous cell types found around the airspaces, including alveolar type 2 cells, alveolar macrophages, and polymorphonuclear neutrophils.
Using a bacteria-induced lung injury model in rats, VEGF expression in lung was investigated. Both VEGF protein and VEGF messenger ribonucleic acid (mRNA), 4 and 24 h after bacterial challenge (Pseudomonas aeruginosa), were decreased compared with sham rats.
VEGF protein was also investigated in bronchoalveolar lavage (BAL) from patients studied within 7 days of acute respiratory distress syndrome (ARDS) onset and in patients without ARDS. VEGF protein levels in BAL were decreased in patients with ARDS versus those without (14.3±11.1 pg·mL–1 versus 76.8±51.1 pg·mL–1, p=0.03).
In aggregate, these findings show that the initial phase of acute lung injury is associated with a decrease in vascular endothelial growth factor in the lung. This downregulation may represent a protective mechanism aimed at limiting endothelial permeability, and may participate in the decrease in capillary number that is observed during early acute respiratory distress syndrome.
This article has been cited by other articles:
|
|
 |
|
  R Zhai, M N Gong, W Zhou, T B Thompson, P Kraft, L Su, and D C Christiani Genotypes and haplotypes of the VEGF gene are associated with higher mortality and lower VEGF plasma levels in patients with ARDS Thorax, August 1, 2007; 62(8): 718 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. McCarter, S. H. J. Mei, P. F. H. Lai, Q. W. Zhang, C. H. Parker, R. S. Suen, R. D. Hood, Y. D. Zhao, Y. Deng, R. N. N. Han, et al. Cell-based Angiopoietin-1 Gene Therapy for Acute Lung Injury Am. J. Respir. Crit. Care Med., May 15, 2007; 175(10): 1014 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Siner, G. Jiang, Z. I. Cohen, P. Shan, X. Zhang, C. G. Lee, J. A. Elias, and P. J. Lee VEGF-induced heme oxygenase-1 confers cytoprotection from lethal hyperoxia in vivo FASEB J, May 1, 2007; 21(7): 1422 - 1432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Kunig, V. Balasubramaniam, N. E. Markham, G. Seedorf, J. Gien, and S. H. Abman Recombinant human VEGF treatment transiently increases lung edema but enhances lung structure after neonatal hyperoxia Am J Physiol Lung Cell Mol Physiol, November 1, 2006; 291(5): L1068 - L1078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mirzapoiazova, I. Kolosova, P. V. Usatyuk, V. Natarajan, and A. D. Verin Diverse effects of vascular endothelial growth factor on human pulmonary endothelial barrier and migration Am J Physiol Lung Cell Mol Physiol, October 1, 2006; 291(4): L718 - L724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A R L Medford and A B Millar Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm? Thorax, July 1, 2006; 61(7): 621 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Kunig, V. Balasubramaniam, N. E. Markham, D. Morgan, G. Montgomery, T. R. Grover, and S. H. Abman Recombinant human VEGF treatment enhances alveolarization after hyperoxic lung injury in neonatal rats Am J Physiol Lung Cell Mol Physiol, October 1, 2005; 289(4): L529 - L535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. B. Ware, R. J. Kaner, R. G. Crystal, R. Schane, N. N. Trivedi, D. McAuley, and M. A. Matthay VEGF levels in the alveolar compartment do not distinguish between ARDS and hydrostatic pulmonary oedema Eur. Respir. J., July 1, 2005; 26(1): 101 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Sack, M. Hoffmann, X. J. Zhao, K. S. Chan, D. S. C. Hui, H. Gosse, L. Engelmann, J. Schauer, F. Emmrich, and G. Hoheisel Vascular endothelial growth factor in pleural effusions of different origin Eur. Respir. J., April 1, 2005; 25(4): 600 - 604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A R L Medford, L J Keen, J L Bidwell, and A B Millar Vascular endothelial growth factor gene polymorphism and acute respiratory distress syndrome Thorax, March 1, 2005; 60(3): 244 - 248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G D Perkins, J Roberts, D F McAuley, L Armstrong, A Millar, F Gao, and D R Thickett Regulation of vascular endothelial growth factor bioactivity in patients with acute lung injury Thorax, February 1, 2005; 60(2): 153 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Abadie, F. Bregeon, L. Papazian, F. Lange, B. Chailley-Heu, P. Thomas, P. Duvaldestin, S. Adnot, B. Maitre, and C. Delclaux Decreased VEGF concentration in lung tissue and vascular injury during ARDS Eur. Respir. J., January 1, 2005; 25(1): 139 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mura, C. C. dos Santos, D. Stewart, and M. Liu Vascular endothelial growth factor and related molecules in acute lung injury J Appl Physiol, November 1, 2004; 97(5): 1605 - 1617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Favre, M. Mancuso, K. Maas, J. W. McLean, P. Baluk, and D. M. McDonald Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H1917 - H1938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Ohwada, Y Yoshioka, K Iwabuchi, I Nagaoka, T Dambara, and Y Fukuchi VEGF regulates the proliferation of acid-exposed alveolar lining epithelial cells Thorax, April 1, 2003; 58(4): 328 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Keane, S. C. Donnelly, J. A. Belperio, R. B. Goodman, M. Dy, M. D. Burdick, M. C. Fishbein, and R. M. Strieter Imbalance in the Expression of CXC Chemokines Correlates with Bronchoalveolar Lavage Fluid Angiogenic Activity and Procollagen Levels in Acute Respiratory Distress Syndrome J. Immunol., December 1, 2002; 169(11): 6515 - 6521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Thickett, L. Armstrong, and A. B. Millar A Role for Vascular Endothelial Growth Factor in Acute and Resolving Lung Injury Am. J. Respir. Crit. Care Med., November 15, 2002; 166(10): 1332 - 1337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Karmpaliotis, I. Kosmidou, E. P. Ingenito, K. Hong, A. Malhotra, M. E. Sunday, and K. J. Haley Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury Am J Physiol Lung Cell Mol Physiol, September 1, 2002; 283(3): L585 - L595. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
