| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 National Public Health Institute, Oulu, Finland, 2 Dean Medical Center, Madison, Wisconsin, USA, 3 National Public Health Institute, Helsinki, Finland. 4 Dept of Medical Microbiology, University of Oulu, Oulu, Finland
CORRESPONDENCE: T. Huittinen, National Public Health Institute, P.O. Box 310, FIN-90101, Oulu, Finland. Fax: 35885376251
Keywords: Asthma, Chlamydia pneumoniae, heat shock protein, serology
Received: October 12, 2000
Accepted January 25, 2001
This study was supported by a grant from the Sigrid Juselius Foundation and the contract BIO4-CT96-0152 of the Biotechnology Programme of the Commission of the European Union.
Chlamydia pneumoniae infection has been associated with asthma. It has also been suggested that heat shock protein 60 (Hsp60) belonging to a class of highly conserved proteins may play a role in the pathogenesis of chlamydial infections. The purpose was to study whether the host immune response to C. pneumoniae Hsp60 is associated with asthma and decreased pulmonary function.
An enzyme immunoassay was used to measure immunoglobulin-(Ig)A and IgG antibodies against recombinant C. pneumoniae Hsp60 and human Hsp60 in a study group consisting of 24 cases of recently symptomatic asthma and 62 nonasthmatic controls.
A strong (r=0.50) and significant (p<0.001) correlation was observed between C. pneumoniae and human Hsp60 IgA antibodies, but only C. pneumoniae Hsp60 IgA antibodies were significantly associated with asthma (p=0.02). Pulmonary function, as measured by forced expiratory volume in one second, also inversely correlated (r=–0.23, p=0.04) with the quantity of C. pneumoniae Hsp60 IgA antibodies, suggesting an association with the severity of pulmonary obstruction.
By showing an association of Chlamydia pneumoniae heat shock protein 60 immunoglobulin A antibodies with asthma, the results support the hypothesis of an association between Chlamydia pneumoniae infection and asthma and support the need for further investigations on the role of heat shock protein 60 in the pathogenesis of asthma.
This article has been cited by other articles:
|
|
 |
|
  A. Palikhe, M.-L. Lokki, P. Saikku, M. Leinonen, M. Paldanius, M. Seppanen, V. Valtonen, M. S. Nieminen, and J. Sinisalo Association of Chlamydia pneumoniae Infection with HLA-B*35 in Patients with Coronary Artery Disease Clin. Vaccine Immunol., January 1, 2008; 15(1): 55 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Johnston and R. J. Martin Chlamydophila pneumoniae and Mycoplasma pneumoniae: A Role in Asthma Pathogenesis? Am. J. Respir. Crit. Care Med., November 1, 2005; 172(9): 1078 - 1089. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. C. Gencay, M. Tamm, A. Glanville, A. P. Perruchoud, and M. Roth Chlamydia pneumoniae Activates Epithelial Cell Proliferation via NF-{kappa}B and the Glucocorticoid Receptor Infect. Immun., October 1, 2003; 71(10): 5814 - 5822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Huittinen, M. Leinonen, L. Tenkanen, H. Virkkunen, M. Manttari, T. Palosuo, V. Manninen, and P. Saikku Synergistic Effect of Persistent Chlamydia pneumoniae Infection, Autoimmunity, and Inflammation on Coronary Risk Circulation, May 27, 2003; 107(20): 2566 - 2570. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Huittinen, M. Leinonen, L. Tenkanen, M. Manttari, H. Virkkunen, T. Pitkanen, E. Wahlstrom, T. Palosuo, V. Manninen, and P. Saikku Autoimmunity to Human Heat Shock Protein 60, Chlamydia pneumoniae Infection, and Inflammation in Predicting Coronary Risk Arterioscler. Thromb. Vasc. Biol., March 1, 2002; 22(3): 431 - 437. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
