| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Asthma Centre of the University Health Network, Toronto, Ontario, Canada and 2 Dept of Medicine, Division of Respiratory Medicine, University of Toronto, Toronto, Ontario, Canada
CORRESPONDENCE: K.R. Chapman, Suite 4-011 ECW, 399 Bathurst Street, Toronto, Ontario, Canada. Fax: 1 4166033456
Keywords: asthma, chronic obstructive pulmonary disease, diffusion capacity, forced expiratory volume in one second, nitric oxide
The following study was undertaken in order to determine how exhaled nitric oxide (eNO) levels in former smokers with chronic obstructive pulmonary disease (COPD) compared to eNO levels in patients with asthma and in healthy nonsmoking volunteers. The study also aimed to determine any relationship between eNO levels in COPD and: 1) conventional measures of lung function; and 2) inhaled corticosteroid (ICS) use.
In former smokers with COPD, nonsmokers with asthma and volunteers, eNO levels, spirometry, lung volumes, carbon monoxide diffusion capacity of the lung (DL,CO) and resting oxygen saturation (Sa,O2) were measured.
Median eNO was significantly higher among patients with COPD than among healthy volunteers (p=0.003) but lower than among patients with asthma (p<0.01). There was no significant difference in eNO levels between COPD patients using ICS and those not using ICS. By contrast, eNO was lower among asthma patients who used ICS (median 32 parts per billion (ppb); 25–75% range 16–54) than among asthma patients who did not (51 ppb; 32–87) (p=0.034). Among patients with COPD, eNO was inversely correlated with forced expiratory volume in one second, DL,CO and Sa,O2, and was positively correlated with the residual lung volume/total lung capacity ratio. Among patients with asthma, no significant correlations were found.
Exhaled nitric oxide is increased in patients with chronic obstructive pulmonary disease, an increase that is influenced by structural abnormalities of tobacco-induced lung damage.
This article has been cited by other articles:
|
|
 |
|
  R. Jiang, R G. Barr, C. A Camargo Jr, W. C Willett, R. Varraso, and D. C Paik Reply to CK Chow Am. J. Clinical Nutrition, December 1, 2008; 88(6): 1704 - 1704. [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. Tadie, P. Henno, I. Leroy, C. Danel, E. Naline, C. Faisy, M. Riquet, M. Levy, D. Israel-Biet, and C. Delclaux Role of nitric oxide synthase/arginase balance in bronchial reactivity in patients with chronic obstructive pulmonary disease Am J Physiol Lung Cell Mol Physiol, March 1, 2008; 294(3): L489 - L497. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D R Taylor, M W Pijnenburg, A D Smith, and J C D Jongste Exhaled nitric oxide measurements: clinical application and interpretation Thorax, September 1, 2006; 61(9): 817 - 827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Choi, L. A. Hoffman, G. W. Rodway, and J. M. Sethi Markers of lung disease in exhaled breath: nitric oxide. Biol Res Nurs, April 1, 2006; 7(4): 241 - 255. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Bhowmik, T. A. R. Seemungal, G. C. Donaldson, and J. A. Wedzicha Effects of exacerbations and seasonality on exhaled nitric oxide in COPD Eur. Respir. J., December 1, 2005; 26(6): 1009 - 1015. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Yasuda, M. Yamaya, K. Nakayama, S. Ebihara, T. Sasaki, S. Okinaga, D. Inoue, M. Asada, M. Nemoto, and H. Sasaki Increased Arterial Carboxyhemoglobin Concentrations in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., June 1, 2005; 171(11): 1246 - 1251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.M. Verleden, L.J. Dupont, M. Delcroix, D. Van Raemdonck, J. Vanhaecke, T. Lerut, and M. Demedts Exhaled nitric oxide after lung transplantation: impact of the native lung Eur. Respir. J., March 1, 2003; 21(3): 429 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Bowler and J. D. Crapo Oxidative Stress in Airways: Is There a Role for Extracellular Superoxide Dismutase? Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): S38 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. M. FERREIRA, M. S. HAZARI, C. GUTIERREZ, N. ZAMEL, and K. R. CHAPMAN Exhaled Nitric Oxide and Hydrogen Peroxide in Patients with Chronic Obstructive Pulmonary Disease . Effects of Inhaled Beclomethasone Am. J. Respir. Crit. Care Med., September 15, 2001; 164(6): 1012 - 1015. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
