HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Permissions Request Permissions Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (16) Citing Articles via Google Scholar Google Scholar Articles by Ferrigno, D. Articles by Ricca, I. Search for Related Content PubMed PubMed Citation Articles by Ferrigno, D. Articles by Ricca, I.

Prognostic significance of blood coagulation tests in lung cancer

¹ Division of Respiratory Medicine, S. Croce e Carle Hospital, Cuneo. ² Dept of Oncology-Haemathology, San Giovanni Battista Hospital, Torino, Italy

CORRESPONDENCE: D. Ferrigno, Divisione di Pneumologia, Ospedale "S. Croce e Carle", I-12100, Cuneo, Italy. Fax: 39 171441764

Keywords: blood coagulation, lung cancer, prethrombotic state, prognosis

Received: May 9, 2000
Accepted November 8, 2000

This study was funded by the Cuneo Lung Cancer Study Group

Previous studies have shown that activation of coagulation has an impact on the clinical course of lung cancer.

This study was carried out to assess the potential prognostic significance of platelet count (P), prothrombin time (PT), partial thromboplastin time (PTT), anti-thrombin III (AT-III), fibrinogen (F), D-dimer (DD), factor II (F-II), factor VII (F-VII), factor X (F-X), protein C clotting (PCC), plasminogen (PL), and antiplasmin (AP) in 343 consecutive new lung cancer patients. A set of 32 anthropometric, clinical, physical, laboratory, radiological, and pathological variables was recorded prospectively for all patients. Patients were carefully followed-up, and their subsequent clinical course recorded.

The most frequent abnormalities were of DD, F, and AT-III followed by F-VII, F-X, and F-II. Among the 12 clotting variables, the strongest relationships were those of F-II and F-X (Spearman rank (r_s)=0.565), PT and F-VII (r_s=0.562), F-VII and F-X (r_s=0.514), PL and AP (r_s=0.515), F and P (r_s=0.490), AT-III and PCC (r_s=0.476). Univariate analyses of survival showed that prolonged PT (p<0.043), and abnormally elevated DD (p<0.003), F (p<0.031), and P (p<0.047) were all associated with a poor prognosis. The multivariate model, however, did not confirm the prognostic significance of the coagulation factors.

The results show subclinical activation of blood coagulation in lung cancer patients with early disease. In addition, clotting activation is confirmed as a predictor of survival, although not independently of other prognostic factors.

This article has been cited by other articles:

				H.-C. Kwon, S. Y. Oh, S. Lee, S.-H. Kim, J. Y. Han, R. Y. Koh, M. C. Kim, and H.-J. Kim Plasma Levels of Prothrombin Fragment F1+2, D-dimer and Prothrombin Time Correlate with Clinical Stage and Lymph Node Metastasis in Operable Gastric Cancer Patients Jpn. J. Clin. Oncol., January 1, 2008; 38(1): 2 - 7. [Abstract] [Full Text] [PDF]

				G. J. Laurent No Bit PARt for PAR-1 Am. J. Respir. Cell Mol. Biol., September 1, 2005; 33(3): 213 - 215. [Full Text] [PDF]