Bronchodilator responsiveness and serum total IgE levels in families of probands with severe early-onset COPD

Bronchodilator responsiveness has been associated with a subsequent accelerated decline in forced expiratory volume in one second (FEV1). Therefore, bronchodilator responsiveness and total serum immunoglobulin E(IgE) levels were assessed in 184 adult first-degree relatives of probands with severe early-onset chronic obstructive pulmonary disease (COPD) and a control group. Greater bronchodilator responsiveness was found among current smokers or exsmokers who were first-degree relatives of early-onset COPD probands than in currently or exsmoking controls, expressed as increase in FEV1 as a percentage of baseline (5.8+/-8.1 versus 2.9+/-5.1%, p<0.01), absolute increase in FEV1 from baseline (120+/-130 versus 60+/-110 mL, p<0.05), and increase in FEV1 as a percentage of the predicted value (3.6:4.1 versus 2.2+/-3.9%, p<0.05). However, elevated total serum IgE levels were not found in first-degree relatives of early-onset COPD probands compared with control subjects. The increased bronchodilator responsiveness among currently smoking/exsmoking first-degree relatives of early-onset COPD probands suggests that these individuals may have enhanced susceptibility to the detrimental effects of cigarette smoking.

This article has been cited by other articles:

				J. M. Brehm and J. C. Celedon Chronic Obstructive Pulmonary Disease in Hispanics Am. J. Respir. Crit. Care Med., March 1, 2008; 177(5): 473 - 478. [Abstract] [Full Text] [PDF]

				C. P Hersh, M. E Soto-Quiros, L. Avila, S. L Lake, C. Liang, E. Fournier, M. Spesny, J. S Sylvia, R. Lazarus, T. Hudson, et al. Genome-wide linkage analysis of pulmonary function in families of children with asthma in Costa Rica Thorax, March 1, 2007; 62(3): 224 - 230. [Abstract] [Full Text] [PDF]

				C. P. Hersh, D. L. DeMeo, E. Al-Ansari, V. J. Carey, J. J. Reilly, L. C. Ginns, and E. K. Silverman Predictors of Survival in Severe, Early Onset COPD Chest, November 1, 2004; 126(5): 1443 - 1451. [Abstract] [Full Text] [PDF]

				L. J. Palmer, J. C. Celedon, H. A. Chapman, F. E. Speizer, S. T. Weiss, and E. K. Silverman Genome-wide linkage analysis of bronchodilator responsiveness and post-bronchodilator spirometric phenotypes in chronic obstructive pulmonary disease Hum. Mol. Genet., May 15, 2003; 12(10): 1199 - 1210. [Abstract] [Full Text] [PDF]

				A J Sandford and E K Silverman Chronic obstructive pulmonary disease * 1: Susceptibility factors for COPD the genotype-environment interaction Thorax, August 1, 2002; 57(8): 736 - 741. [Abstract] [Full Text] [PDF]

				E. K. Silverman Genetic Epidemiology of COPD Chest, March 1, 2002; 121(2007): 1S - 6S. [Abstract] [Full Text] [PDF]

				E. K. SILVERMAN, S. T. WEISS, J. M. DRAZEN, H. A. CHAPMAN, V. CAREY, E. J. CAMPBELL, P. DENISH, R. A. SILVERMAN, J. C. CELEDON, J. J. REILLY, et al. Gender-Related Differences in Severe, Early-Onset Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., December 1, 2000; 162(6): 2152 - 2158. [Abstract] [Full Text]