| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Articles |
The aim of this study was to examine the role of p38 mitogen-activated protein (MAP) kinase in interleukin (IL)-8 expression in tumour necrosis factor (TNF)-alpha- and IL-1alpha-stimulated human pulmonary vascular endothelial cells. To this end, the phosphorylation and activation of p38 MAP kinase and the effect of SB 203580, a specific inhibitor of p38 MAP kinase activity, on p38 MAP kinase activity and IL-8 expression in TNF-alpha- and IL-1alpha-stimulated human pulmonary vascular endothelial cells were examined. TNF-alpha- and IL-1alpha- induced phosphorylation and activation of p38 MAP kinase and IL-8 expression in human pulmonary endothelial cells. Inhibition of TNF-alpha- and IL-1alpha-induced p38 MAP kinase activity by SB 203580 inhibited TNF-alpha- and IL-1alpha-induced IL-8 protein production as well as IL-8 messenger ribonucleic acid (mRNA) expression, indicating that SB 203580 was effective at the transcriptional level. These results indicate that p38 mitogen-activated protein kinase plays an important role in the tumour necrosis factor-alpha- and interleukin-1alpha-activated signalling pathway which regulates interleukin-8 expression in human pulmonary vascular endothelial cells.
This article has been cited by other articles:
|
|
 |
|
  G. Rajashekhar, M. Grow, A. Willuweit, C. E. Patterson, and M. Clauss Divergent and convergent effects on gene expression and function in acute versus chronic endothelial activation Physiol Genomics, September 11, 2007; 31(1): 104 - 113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Cao, L. Cheng, J. Behar, P. Biancani, and K. M. Harnett IL-1beta signaling in cat lower esophageal sphincter circular muscle Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G672 - G680. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Niwano, M. Arai, N. Koitabashi, S. Hara, A. Watanabe, K. Sekiguchi, T. Tanaka, T. Iso, and M. Kurabayashi Competitive Binding of CREB and ATF2 to cAMP/ATF Responsive Element Regulates eNOS Gene Expression in Endothelial Cells Arterioscler. Thromb. Vasc. Biol., May 1, 2006; 26(5): 1036 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Heit, P. Colarusso, and P. Kubes Fundamentally different roles for LFA-1, Mac-1 and {alpha}4-integrin in neutrophil chemotaxis J. Cell Sci., November 15, 2005; 118(22): 5205 - 5220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. E. Nwariaku, P. Rothenbach, Z. Liu, X. Zhu, R. H. Turnage, and L. S. Terada Rho inhibition decreases TNF-induced endothelial MAPK activation and monolayer permeability J Appl Physiol, November 1, 2003; 95(5): 1889 - 1895. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-F. Li, B. Ouyang, G. Choukroun, R. Matyal, M. Mascarenhas, B. Jafari, J. V. Bonventre, T. Force, and D. A. Quinn Stretch-induced IL-8 depends on c-Jun NH2-terminal and nuclear factor-{kappa}B-inducing kinases Am J Physiol Lung Cell Mol Physiol, August 1, 2003; 285(2): L464 - L475. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Sakamoto, T. Tosaki, and Y. Nakagawa Overexpression of Phospholipid Hydroperoxide Glutathione Peroxidase Modulates Acetyl-CoA, 1-O-Alkyl-2-lyso-sn-glycero-3-phosphocholine Acetyltransferase Activity J. Biol. Chem., December 20, 2002; 277(52): 50431 - 50438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, S. Kartha, S. Iasvovskaia, A. Tan, R. K. Bhat, J. M. Manaligod, K. Page, A. R. Brasier, and M. B. Hershenson Regulation of human airway epithelial cell IL-8 expression by MAP kinases Am J Physiol Lung Cell Mol Physiol, October 1, 2002; 283(4): L690 - L699. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Marin, C. Farnarier, S. Gres, S. Kaplanski, M. S.-S. Su, C. A. Dinarello, and G. Kaplanski The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment Blood, August 1, 2001; 98(3): 667 - 673. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Alcorn, J. L. Booth, K. M. Coggeshall, and J. P. Metcalf Adenovirus Type 7 Induces Interleukin-8 Production via Activation of Extracellular Regulated Kinase 1/2 J. Virol., July 15, 2001; 75(14): 6450 - 6459. [Abstract] [Full Text]
|
|
|
|
 |
|
 Z.-M. Bian, V. M. Elner, A. Yoshida, S. L. Kunkel, and S. G. Elner Signaling Pathways for Glycated Human Serum Albumin-Induced IL-8 and MCP-1 Secretion in Human RPE Cells Invest. Ophthalmol. Vis. Sci., June 1, 2001; 42(7): 1660 - 1668. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Hashimoto, Y. Gon, K. Matsumoto, S. Maruoka, I. Takeshita, S. Hayashi, Y. Asai, Y. Asai, I. Jibiki, T. Machino, et al. Selective Inhibitor of p38 Mitogen-Activated Protein Kinase Inhibits Lipopolysaccharide-Induced Interleukin-8 Expression in Human Pulmonary Vascular Endothelial Cells J. Pharmacol. Exp. Ther., May 1, 2000; 293(2): 370 - 375. [Abstract] [Full Text]
|
|
|
|
|
|
J.-P. Gratton, M. Morales-Ruiz, Y. Kureishi, D. Fulton, K. Walsh, and W. C. Sessa Akt Down-regulation of p38 Signaling Provides a Novel Mechanism of Vascular Endothelial Growth Factor-mediated Cytoprotection in Endothelial Cells J. Biol. Chem., August 3, 2001; 276(32): 30359 - 30365. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
